The Rhinovirus Hospitalization and Investigation of Nasal-airway Omics (RHINO) Study

Inclusion Criteria (Aim 1 and Aim 2b Community Groups): * Parent/legal guardian is willing and able to provide informed consent in English. * Willing to comply with all study procedures and be available for the duration of the study. * Younger Community Group: Generally healthy children 12 to 36 months of age at the time of enrollment * Older Community Group: Generally healthy children 5 to 17.5 years of age at the time of enrollment. * Current patient within primary care system at UW Health Inclusion Criteria (Aim 2a: Hospitalized Group): * Parent/legal guardian is willing and able to provide informed consent in English. * Admitted to American Family Children's Hospital (AFCH) within the past 24 hours * Children under 17.5 years of age at the time of enrollment * Has a diagnosis of bronchiolitis, asthma exacerbation, acute hypoxemic respiratory failure or community acquired pneumonia (CAP) OR is an infant less than 6 months of age with fever greater than 38 degrees Celsius within 24 hours of hospital admission Exclusion Criteria (all participants): * Congenital or currently acquired immunosuppressive condition or medications (e.g., congenital immunodeficiency, Leukemia, Lupus) * Congenital anomalies that might alter frequency of infection (e.g., unrepaired cleft palate, bronchial cyst, pulmonary sequestration) * Presence of tracheostomy or gastrostomy tube * Previously enrolled a different group in the study * Other child in the same household already enrolled in the study * Not suitable for study participation due to other reasons at the discretion of the investigators. Exclusion Criteria (Aim 1: Community Group Only): * History of chronic pulmonary diseases (e.g., asthma, cystic fibrosis, bronchopulmonary dysplasia (BPD)) (Note: asthma IS exclusionary) * Acute upper respiratory symptoms within the past week (7 days) at the time of enrollment Exclusion Criteria (Aim 2: Hospitalized Group Only): * History of chronic pulmonary diseases, excluding asthma (e.g., cystic fibrosis, bronchopulmonary dysplasia (BPD)) (Note: asthma is NOT exclusionary) * A positive test for any virus other than RV within the 48 hours prior to and including admission. * Non-respiratory infection at the time of admission * Neurologic disease (for example, cerebral palsy, genetic neurologic diseases, seizure disorder) Exclusion Criteria (less than 5 years old only (All participants in Aim 1 and some participants in Aim 2a): * Born prematurely, less than 32 weeks 0 days gestational age