No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
200 (estimated)
Sponsor
Capital Medical University · Other
Who this trial is looking for
This trial is looking for adults who have been on a ventilator for a long time and need help with breathing. Participants will receive special physiotherapy that uses real-time imaging to customize their care compared to standard therapy.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old.
I have been on a ventilator for at least 21 days.
I am stable enough to receive respiratory physiotherapy.
I will remain on the ventilator for at least 48 hours after joining.
I have provided written consent to participate.
You may not be able to join if
I cannot undergo electrical impedance tomography.
I am unstable and need high doses of medications to support blood pressure.
I have severe low oxygen levels that cannot be improved.
I have unstable fractures that prevent me from moving.
I am pregnant.
I am expected to die within the next 48 hours.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
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Answer a few quick questions to see if you may meet the eligibility requirements.
Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation. Electrical impedance tomography (EIT) provides real-time bedside visualization of regional ventilation and enables individualized respiratory physiotherapy strategies.
This multicenter…
Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation. Electrical impedance tomography (EIT) provides real-time bedside visualization of regional ventilation and enables individualized respiratory physiotherapy strategies.
This multicenter randomized controlled trial aims to evaluate whether EIT-guided respiratory physiotherapy improves ventilator-free days at day 28 compared with conventional respiratory physiotherapy in adult patients with PMV.
Respiratory physiotherapy consists of airway clearance, chest physiotherapy techniques, breathing pattern optimization, and therapeutic positioning. In the EIT-guided group, real-time EIT imaging is used to individualize physiotherapy strategies based on predefined ventilation distribution indicators, while the control group receives standardized physiotherapy according to institutional protocols without EIT guidance.
Secondary outcomes include successful liberation from mechanical ventilation, diaphragm ultrasound parameters, EIT-derived ventilation distribution indices (exploratory mechanistic outcomes), ICU Mobility Scale, healthcare resource utilization, and safety outcomes.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Age ≥ 18 years.
* Invasive mechanical ventilation for ≥ 21 consecutive days.
* Clinically stable and eligible for respiratory physiotherapy as determined by the treating team.
* Expected to remain on invasive mechanical ventilation for at least 48 hours after enrollment.
* Wri…
Inclusion Criteria:
* Age ≥ 18 years.
* Invasive mechanical ventilation for ≥ 21 consecutive days.
* Clinically stable and eligible for respiratory physiotherapy as determined by the treating team.
* Expected to remain on invasive mechanical ventilation for at least 48 hours after enrollment.
* Written informed consent obtained from the patient or legally authorized representative.
Exclusion Criteria:
* Contraindications to electrical impedance tomography .
* Hemodynamic instability requiring high-dose vasoactive support.
* Severe hypoxemia refractory to optimization.
* Unstable fractures or other contraindications to mobilization or positioning.
* Pregnancy.
* Expected death within 48 hours.
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