No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
40 and older
Sex
Any
Study type
Interventional
Purpose
Supportive Care
Participants needed
46 (estimated)
Sponsor
Emory University · Other
Who this trial is looking for
This trial is looking for older adults with mild to moderate Parkinson's disease. Participants will take part in guided exercise sessions three times a week for three weeks, with some monitored remotely.
Are You a Good Fit for This Trial?
Must not be takingAntipsychoticsOpioidsStimulantsChemotherapy
Rules you outAcute medical illnessStroke with neurological effectsSubstance Use DisorderMajor Depressive DisorderGeneralized Anxiety Disorder
You may be able to join if
I am an older adult.
I have been diagnosed with mild to moderate Parkinson's disease.
You may not be able to join if
I am under 40 years old.
I have had an acute medical illness that required hospitalization.
I have uncontrolled heart failure.
I have had a stroke in the past three years.
I cannot perform the study procedures.
I have severe arthritis or mobility problems.
I have uncontrolled hypertension or diabetes.
I have a history of psychotic disorders.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study will evaluate exercise delivered through the Zesty Exercise System for Therapeutic Engagement (ZEST-E) for people with Parkinson's disease when sessions are monitored either in person or remotely. Participants will complete robot-guided exercise three times per week for three weeks. The study will assess feasibility, retention, safety, acceptability, and tolerability of remotely monitor…
This study will evaluate exercise delivered through the Zesty Exercise System for Therapeutic Engagement (ZEST-E) for people with Parkinson's disease when sessions are monitored either in person or remotely. Participants will complete robot-guided exercise three times per week for three weeks. The study will assess feasibility, retention, safety, acceptability, and tolerability of remotely monitored ZEST-E and will measure changes in functional performance using the Standing Forward Reach test and the 30-Second Chair Stand test. These outcomes reflect range of motion and lower-body strength targeted by the exercise program.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
-Older adults with mild to moderate PD.
Exclusion Criteria:
* Acute medical illness requiring hospitalization;
* Under 40 years old;
* Uncontrolled congestive heart failure;
* History of stroke in the past three years;
* Inability to perform study procedures;
* Medical or phys…
Inclusion Criteria:
-Older adults with mild to moderate PD.
Exclusion Criteria:
* Acute medical illness requiring hospitalization;
* Under 40 years old;
* Uncontrolled congestive heart failure;
* History of stroke in the past three years;
* Inability to perform study procedures;
* Medical or physical conditions that would preclude participation (e.g., severe arthritis or mobility problems, uncontrolled hypertension or diabetes, renal failure, history of angina with activity);
* On medications that could adversely affect cognition, e.g.: antipsychotics, opioids, stimulants, chemotherapy;
* Psychotic disorders;
* Confounding neurologic conditions (e.g., active central nervous system opportunistic infections, seizure disorders, head injury with loss of consciousness \>30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae);
* Substance Use Disorder, Major Depressive and Generalized Anxiety Disorders within six months of evaluation;
* Hohn \& Yahr \> 3
* MoCA \<17
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