Insulin-Mediated Glucose Uptake and Organ Perfusion Assessed by Total-Body PET During GIP and GLP-1 Infusion
Recruiting
N/A
Interventional Study
Type 2 Diabetes
Healhty
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 23 – 64
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 36 (estimated)
- Sponsor
- Rigshospitalet, Denmark · Other
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About This Trial
This study investigates how the naturally occurring gut hormones GIP and GLP-1 influence whole-body glucose uptake and organ perfusion in humans. Using a state-of-the-art total-body PET-CT scanner, the study measures dynamic uptake of the glucose analogue 18F-FDG and blood flow using H₂¹⁵O across multiple organs during controlled elevations of plasma glucose and endogenous insulin secretion.
The …
Trial Locations
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Eligibility Criteria
Sub-study 1 (Healthy individuals):
* Age 23-50 years
* BMI 20.0-26.9 kg/m²
* HbA1c \< 42 mmol/mol
* Able to provide informed consent
Sub-study 2 - Participants with Type 2 Diabetes:
* Age 23-60 years
* Diagnosed with type 2 diabetes for ≥3 months
* HbA1c \> 53 mmol/mol
* Treatment with metformin …
Contacts