Accelerated iTBS for Apathy in Parkinson's Disease
Accelerated rTMS for Apathy in Parkinson's Disease
Recruiting
N/A
Interventional Study
Parkinson Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 45 – 85
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 15 (estimated)
- Sponsor
- Medical University of South Carolina · Other
Who this trial is looking for
This trial is looking for people with Parkinson's Disease who experience apathy. Participants will receive a series of brain stimulation treatments over two weeks and will be monitored for changes in their symptoms.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 45 and 85 years old.
- I have been diagnosed with Parkinson's Disease.
- I have significant apathy.
- I have stable Parkinson's medications.
- I have a caregiver who can inform about my condition.
You may not be able to join if
- I cannot have MRI or TMS treatments.
- I have severe cognitive impairment.
- I have a history of bipolar disorder or schizophrenia.
- I have had a seizure before.
- I have thought about suicide recently or attempted it in the past year.
- I am pregnant.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
This single-site, open-label pilot study will evaluate the feasibility, tolerability, and preliminary efficacy of accelerated intermittent theta-burst stimulation (iTBS) targeting the dorsomedial prefrontal cortex (dmPFC) for apathy in individuals with Parkinson's Disease (PD). Fifteen participants with PD and clinically significant apathy will undergo six treatment visits over two weeks, receivin…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 45-85
* Diagnosis of Parkinson's Disease
* AES ≥37
* Stable PD medications
* Caregiver informant available
Exclusion Criteria:
* MRI/TMS contraindications
* Severe cognitive impairment (MoCA \<21)
* Psychiatric disorders (bipolar, schizophrenia, active substance use diso…
Contacts
No contact information available.