Accelerated TMS for Apathy in PD

Recruiting N/A Interventional Study
Parkinson Disease
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
45 – 85
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
15 (estimated)
Sponsor
Medical University of South Carolina · Other
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About This Trial
This single-site, open-label pilot study will evaluate the feasibility, tolerability, and preliminary efficacy of accelerated intermittent theta-burst stimulation (iTBS) targeting the dorsomedial prefrontal cortex (dmPFC) for apathy in individuals with Parkinson's Disease (PD). Fifteen participants with PD and clinically significant apathy will undergo six treatment visits over two weeks, receivin…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age 45-85 * Diagnosis of Parkinson's Disease * AES ≥37 * Stable PD medications * Caregiver informant available Exclusion Criteria: * MRI/TMS contraindications * Severe cognitive impairment (MoCA \<21) * Psychiatric disorders (bipolar, schizophrenia, active substance use diso…
Contacts

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