No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
20 – 45
Sex
Female
Study type
Interventional
Purpose
Treatment
Participants needed
148 (estimated)
Sponsor
Hanoi Medical University · Other
Who this trial is looking for
This trial is looking for women aged 20-45 who need in vitro fertilization (IVF) treatment. Participants will use one of two protocols to stimulate their ovaries and undergo regular monitoring, with the option to freeze embryos for future use.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 20 and 45 years old.
I need in vitro fertilization (IVF) treatment.
I plan to freeze all my embryos.
I agree to participate in research.
You may not be able to join if
I have a systemic disease.
I have used hormonal medications in the past 3 months.
I am involved in an egg donation cycle.
I am unwilling or unable to participate in research.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol. The study will evaluate IVF outcomes and embryo development patterns using time-lapse embryo monitoring technology. The main questions the study aims to answer are:
* Does the fixed - …
The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol. The study will evaluate IVF outcomes and embryo development patterns using time-lapse embryo monitoring technology. The main questions the study aims to answer are:
* Does the fixed - PPOS protocol achieve similar numbers of mature eggs, good-quality embryos, and clinical outcomes compared to the GnRH Antagonist protocol?
* Are there differences in embryo development patterns (morphokinetics) between the two protocols when monitored by time-lapse imaging?
* How does embryo quality (KIDScore) compare between the two protocols?
Study Design:
Researchers will randomly assign 148 women undergoing IVF to two groups:
* PPOS group (n=74): Will receive FSH injections (oral Duphaston 20mg daily) starting from day 2-3 of the menstrual cycle
* GnRH Antagonist group (n=74): Will receive FSH injections (Orgalutran 0.25mg injections) when follicles reach ≥14mm
Participants will:
* Undergo controlled ovarian stimulation with their assigned protocol for approximately 10-12 days
* Have regular ultrasound monitoring and blood tests to track follicle development
* Undergo egg retrieval procedure when follicles are mature
* Have all embryos cultured in the EmbryoScope time-lapse incubator with continuous monitoring
* Have embryos frozen on Day 5/6 for future transfer
Study Location:
Department of Assisted Reproduction and Andrology, Hanoi Obstetrics and Gynecology Hospital
Study Duration: January 2026 - June 2028
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Women aged 20-45 years
* Indicated for in vitro fertilization (IVF) treatment
* Planned freeze-all embryo strategy
* Voluntary participation in research.
Exclusion Criteria:
* Systemic diseases
* Use of hormonal medications within 3 months prior to enrollment
* Oocyte donati…
Inclusion Criteria:
* Women aged 20-45 years
* Indicated for in vitro fertilization (IVF) treatment
* Planned freeze-all embryo strategy
* Voluntary participation in research.
Exclusion Criteria:
* Systemic diseases
* Use of hormonal medications within 3 months prior to enrollment
* Oocyte donation cycles
* Unwilling or unable to participate in research
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