Effects of X-ray Treatment on Red Blood Cells in Surgery
A Multi-dimensional Evaluation of the Effects of Linear Accelerator X-ray Irradiation on Red Blood Cells
Recruiting
Observational Study
Erythrocyte Destruction
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 – 65
Sex
Any
Study type
Observational
Participants needed
20 (estimated)
Sponsor
Second Affiliated Hospital, Zhejiang University, School of Medicine · Other
Who this trial is looking for
This trial is looking for patients who will have surgery for cancer and may lose some blood. Participants will have their blood cells tested to understand how X-ray treatment affects them during the surgery.
Are You a Good Fit for This Trial?
You may be able to join if
I am scheduled for elective surgery for a malignant tumor.
I am between 18 and 65 years old.
I expect to lose 500 milliliters or more of blood during surgery.
You may not be able to join if
I have a disorder affecting red blood cell production.
I have a disease that causes increased destruction of red blood cells.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
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This study aims to investigate the effects of linear accelerator X-ray irradiation on the structure, mechanics and functional characteristics of red blood cells recovered from patients with malignant tumors during surgery. A red blood cell damage evaluation system based on multiple-dimensional indicators is established. Through atomic force microscopy, microfluidic chips and biochemical detection …
This study aims to investigate the effects of linear accelerator X-ray irradiation on the structure, mechanics and functional characteristics of red blood cells recovered from patients with malignant tumors during surgery. A red blood cell damage evaluation system based on multiple-dimensional indicators is established. Through atomic force microscopy, microfluidic chips and biochemical detection methods, the changes in red blood cell membrane structure, deformability and oxygen-carrying capacity under different irradiation doses are systematically evaluated. The dose-effect relationship between irradiation dose and red blood cell damage degree is clarified, providing experimental evidence for the safe dose of irradiation processing of autologous blood during surgery.
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Eligibility Criteria
Inclusion Criteria:
* Patients scheduled for elective surgery for malignant tumors
* Age: 18 - 65 years old
* It is estimated that the surgical bleeding will be greater than or equal to 500 milliliters.
Exclusion Criteria:
* Disorders of red blood cell production (such as aplastic anemia, megalob…
Inclusion Criteria:
* Patients scheduled for elective surgery for malignant tumors
* Age: 18 - 65 years old
* It is estimated that the surgical bleeding will be greater than or equal to 500 milliliters.
Exclusion Criteria:
* Disorders of red blood cell production (such as aplastic anemia, megaloblastic anemia, iron deficiency anemia, leukemia, myelofibrosis, etc.)
* Diseases caused by increased destruction of red blood cells (abnormalities in red blood cell membranes such as hereditary spherocytosis and paroxysmal nocturnal hemoglobinuria; abnormalities in hemoglobin such as thalassemia; abnormalities in red blood cell-related enzymes such as glucose-6-phosphate dehydrogenase deficiency, etc.)
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