Sex Hormones Impact on Cannabis Response

Inclusion Criteria: * Biological female * Used cannabis between 1 time a month and 2 times a week during the previous year * Age between 18 and 40 years * Free from psychotropic medication * Free from hormonal birth control * A regular menstrual cycle (last 3 cycles a duration between 21 and 35 days). * Good physical health as determined by medical examination and laboratory analysis * Absence of any major medical, endocrine and neurological condition as determined by medical examination and laboratory analysis * Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2 * Written Informed Consent * Good knowledge and understanding of the English language * Participants must be willing to refrain from taking illicit psychoactive substances during the study. * Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drinks after midnight of the evening before the study session, as well as during the study day. * Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration. Exclusion Criteria: * History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination) * Pregnancy or lactation or pregnancy planned during study participation * Hypertension (diastolic \> 90 mmHg; systolic \> 140 mmHg) * Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) * Current presence or history of psychosis in first-degree relatives * Any chronic or acute medical condition * History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…) * Tobacco smoking (\>20 per day) * Excessive drinking (\>20 alcoholic consumptions per week)