Response to Neoadjuvant Treatment in Locally Advanced Thyroid Cancer
Recruiting
Observational Study
Thyroid CancerThyroid Neoplasms
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
14 – 80
Sex
Any
Study type
Observational
Participants needed
120 (estimated)
Sponsor
Fujian Medical University · Other
Who this trial is looking for
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This multicenter observational study aims to evaluate the safety and efficacy of neoadjuvant therapy in patients with locally advanced thyroid cancer, focusing on imaging, biochemical, and pathological responses, as well as short-term surgical outcomes and long-term prognosis.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Age ≥ 14 years at enrollment.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
* Histologically or cytologically confirmed thyroid carcinoma, including differentiated thyroid carcinoma (DTC), medullary thyroid carcinoma (MTC), poorly differentiated thyroi…
Inclusion Criteria:
* Age ≥ 14 years at enrollment.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.
* Histologically or cytologically confirmed thyroid carcinoma, including differentiated thyroid carcinoma (DTC), medullary thyroid carcinoma (MTC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carcinoma (ATC).
* LATC defined as clinical stage T4N0-1 at baseline, as confirmed by a multidisciplinary thyroid oncology board.
* For patients with distant metastasis, the potential benefit from surgical intervention must be documented by the treating team.
* Presence of at least one measurable lesion, according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.
* Normal function of major organs.
* Written informed consent obtained.
Exclusion Criteria:
* Patients who refuse tumor tissue biopsy or surgery.
* Prior thyroid or major neck surgery.
* History of other treatments for cancer, including surgery, chemotherapy, radiotherapy, or molecular targeted therapy, that may affect the current treatment plan.
* Concurrent active malignancies.
* Uncontrolled systemic diseases, including diabetes, hypertension, etc.
* Pregnancy or breastfeeding.
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.