Remote Ischemic Preconditioning and Postoperative Neuronal Injury
Recruiting
N/A
Interventional Study
Postoperative Neuronal Injury
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 50 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 216 (estimated)
- Sponsor
- University of Hamburg-Eppendorf · Other
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About This Trial
The SHIELD trial is a single-center, randomized, controlled, parallel-group, single-blinded clinical trial investigating whether performing RIPC one day before surgery-compared to not performing RIPC-reduces postoperative neuronal injury, as reflected by the maximum serum NfL concentration within the first 2 postoperative days, in non-cardiac surgery patients at risk for postoperative delirium.
Trial Locations
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Eligibility Criteria
Inclusion criteria:
* patients (≥50 years) scheduled for elective non-cardiac surgery with general anesthesia
* patients at risk for postoperative delirium, defined as the presence of ≥2 of the following established risk factors: age ≥65 years, American Society of Anesthesiologists physical status …