5-ALA Guided Surgery for Glioblastoma Patients
Clinical Significance of Liquid Biopsy in Brain Tumor Patients: a 5-ALA Guided Approach
Recruiting
Observational Study
Brain Tumors and/or Solid Tumors Including
Glioblastoma
Glioblastoma (GBM)
Glioblastoma - Category
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 30 (estimated)
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Other
Who this trial is looking for
This trial is looking for patients with glioblastoma or other brain tumors who can participate in a surgery using a special dye called 5-ALA. Participating may help improve how doctors manage brain tumors by using information from both blood tests and surgical guidance.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years old or older
- I have been diagnosed with glioblastoma or another brain tumor
- I can give informed consent
- I am suitable for surgery with 5-ALA guidance
You may not be able to join if
- I have other systemic tumors
- I am allergic to gadolinium
- I have devices that are not compatible with MRI
- I have significantly compromised kidney function
- I am undergoing dialysis
- I have conditions that prevent surgery with 5-ALA guidance
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Glioblastoma (GBM) is the most common and lethal primary brain tumor. Identifying blood biomarkers that reflect the tumor's status is a major unmet need for optimal clinical management. 5-ALA (5-Aminolevulinic Acid) administration leads to the accumulation of fluorescent Protoporphyrin IX (PpIX) in GBM cells, allowing identification during surgery. This project aims to leverage 5-ALA induced fluor…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Inclusion Criteria (Glioblastoma Patients):
* Patient aged 18 years or older
* Diagnosis of supratentorial glioblastoma at its first occurrence (Grade 4, WHO 2021), confirmed through histological analysis, in a brain area that is accessible for surgical removal.
* Ability of t…
Contacts