PF-08634404 for Advanced Urothelial Cancer
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
Recruiting
Phase 1
Phase 2
Interventional Study
Urothelial Cancer
Advanced/Metastatic Urothelial Cancer
Urothelial Carcinoma
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 132 (estimated)
- Sponsor
- Pfizer · Industry
Who this trial is looking for
This trial is looking for adults with locally advanced or metastatic bladder cancer. Participants will receive a new medicine either alone or with another treatment, and they will have regular check-ups to monitor their health and cancer.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years or older.
- I have locally advanced or metastatic urothelial cancer.
- My cancer can be measured.
- My overall health is good with an ECOG score of 0 or 1.
- My organ functions are adequate.
- I can follow study procedures and give my consent.
- If applicable, I will use effective birth control during the study.
You may not be able to join if
- I have had another cancer in the past 3 years.
- I have known active lesions in my brain or spinal cord.
- I have had an active autoimmune disease needing treatment in the past 2 years.
- I have participated in another clinical study in the past month.
- I am pregnant or breastfeeding.
- I cannot follow study requirements.
- I am a study staff member or related to one.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
This study is being done to learn more about a new medicine called PF-08634404. It is for adults with a type of bladder cancer called locally advanced or metastatic urothelial cancer (LA/mUC), meaning the cancer has spread to nearby tissues or other parts of the body.
The purpose of the study is to see if PF-08634404 is safe, how well it works, how it moves through the body, and how it affects th…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥18 years at the time of screening.
* Histologically confirmed locally advanced or metastatic urothelial carcinoma (LA/mUC).
* Measurable disease per RECIST v1.1 criteria.
* ECOG performance status of 0 or 1.
* Adequate organ function, including hematologic, hepatic, and r…
Contacts