Cytokine Response to Abdominal Wall Reconstruction
Recruiting
Observational Study
Incisional Ventral Hernia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 25 (estimated)
- Sponsor
- Northwestern University · Other
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About This Trial
This is a prospective, observational translational study of patients undergoing major abdominal wall reconstruction with primary fascial closure. The project integrates perioperative cytokine profiling, direct measurement of intra-abdominal pressure, and detailed clinical outcomes to define the biologic and physiologic consequences of high-tension closure.
The study includes three cohorts: 1) Hea…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
Surgical Participants
* Adults aged 18 years or older
* Scheduled to undergo open retromuscular ventral hernia repair
* Able to provide written informed consent Healthy Control Participants
* Adults aged 18 years or older
* No known inflammatory, autoimmune, or immunologic dise…
Contacts