Multimodal Neuromonitoring During Normothermic Regional Perfusion for Organ Donors Determined Dead by circuLatory Criteria Following Withdrawal of Life Sustaining Measures
Recruiting
Observational Study
Organ Preservation
Brain Reperfusion or Regain of Brain Function During Normothermic Regional Perfusion
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 19 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 30 (estimated)
- Sponsor
- University of British Columbia · Other
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About This Trial
The aim of this study is to demonstrate that cerebral blood flow and brain function do not resume after death declaration in organ donors who undergo normothermic regional perfusion to restore organ function following death determination by circulatory criteria, when appropriate safeguards are applied.
To assess the absence of cerebral perfusion and function, investigators will use continuous and…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age \> 18;
2. Planned DCD within the next 96 hours.
Exclusion Criteria:
1. Coagulopathy (International normalized ratio \> 1.5, prothrombin time \> 45 seconds, platelets \< 50);
2. Therapeutic anticoagulant medication administration.
Contacts