No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 65
Sex
Any
Study type
Interventional
Purpose
Diagnostic
Participants needed
40 (estimated)
Sponsor
The Cleveland Clinic · Other
Who this trial is looking for
This trial is looking for people who are already part of the CAVS-MS study and have completed their 24-month visits. Participants will be followed for 48 months to see how two specific MRI markers help in diagnosing and monitoring multiple sclerosis.
Are You a Good Fit for This Trial?
You may be able to join if
I am enrolled in the CAVS-MS study.
I have completed my month 24 visits.
I can provide written informed consent.
You may not be able to join if
I cannot have an MRI due to metal implants.
I cannot tolerate an MRI because of claustrophobia.
I have excessive movement that prevents me from having an MRI.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Multiple sclerosis (MS) is a common disease of the central nervous system that affects almost 1 million people in the United States. However, diagnosing MS can be difficult and often leads to misdiagnosis. More sensitive and specific biomarkers are needed to help with the diagnosis, prognosis, and evaluation of treatment response for MS. The central vein sign (CVS) and the paramagnetic rim lesion …
Multiple sclerosis (MS) is a common disease of the central nervous system that affects almost 1 million people in the United States. However, diagnosing MS can be difficult and often leads to misdiagnosis. More sensitive and specific biomarkers are needed to help with the diagnosis, prognosis, and evaluation of treatment response for MS. The central vein sign (CVS) and the paramagnetic rim lesion (PRL) are two biomarkers that have shown promise in improving diagnostic accuracy for MS.
The goal of this study is to provide pilot information on the long-term performance of the CVS and PRL to help diagnose and follow people with MS. The study will follow 40 participants over 48 months to determine if the CVS and PRL help make a diagnosis of MS and how they can be used to follow people with MS. The study will also examine how PRL and CVS change over 48 months. The results of this pilot study will inform the development of a grant application to extend 5-year follow-up for all 420 participants of the CAVS-MS study. The study will use high-resolution T2\*-weighted MRI to detect the CVS and PRLs. An MRI of the brain with contrast will be used to examine CVS, PRL and longitudinal analysis of lesions that slowly grow over time (slowly expanding lesions \[SELs\]). The results of this study have the potential to improve the accuracy of diagnosing and treating MS.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Participants must be enrolled in and meet all inclusion criteria of the CAVS-MS study.
* Must have participated in the CAVS-MS study and have completed month 24 visits.
* Able to provide written informed consent to participate in the study.
Exclusion Criteria:
* Contraindica…
Inclusion Criteria:
* Participants must be enrolled in and meet all inclusion criteria of the CAVS-MS study.
* Must have participated in the CAVS-MS study and have completed month 24 visits.
* Able to provide written informed consent to participate in the study.
Exclusion Criteria:
* Contraindication to MRI studies; metal or metal implants incompatible with MRI
* Inability to tolerate MRI due to claustrophobia or known excessive movement (e.g. tremor).
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