No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
40 – 70
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
60 (estimated)
Sponsor
University of Colorado, Denver · Other
Who this trial is looking for
This trial is looking for people with knee arthritis aged 40 to 70 years. Participants will take part in a new exercise program to help improve their ability to climb stairs.
Are You a Good Fit for This Trial?
You may be able to join if
I am aged 40-70 years
I have been diagnosed with knee osteoarthritis
I can walk independently
You may not be able to join if
I have uncontrolled high blood pressure or heart disease
I have a musculoskeletal condition that prevents me from exercising
I have neurological muscle weakness
My BMI is over 34.9
I have been hospitalized in the past 3 months
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength,…
This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods.
The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail.
The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.
Trial Locations
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Eligibility Criteria
Inclusion Criteria Osteoarthritis (OA) Group:
* Aged 40-70 years
* Radiographically confirmed knee OA (Kellgren-Lawrence \[KL\] Grade 2 or 3)
* Able to walk independently (assistive devices permitted)
Inclusion Criteria Healthy Control Group:
* Aged 40-70 years
* No radiographic evidence of knee …
Inclusion Criteria Osteoarthritis (OA) Group:
* Aged 40-70 years
* Radiographically confirmed knee OA (Kellgren-Lawrence \[KL\] Grade 2 or 3)
* Able to walk independently (assistive devices permitted)
Inclusion Criteria Healthy Control Group:
* Aged 40-70 years
* No radiographic evidence of knee OA (KL Grade 0 or 1)
* No frequent knee pain
* No history of:
* Knee surgery (e.g., ACL reconstruction, meniscectomy, patellar realignment)
* Significant knee injury (e.g., ligament tears, fractures, dislocations)
* Diagnosed knee conditions (e.g., patellofemoral pain syndrome, bursitis)
Exclusion Criteria:
* Uncontrolled hypertension or other cardiovascular disease
* A musculoskeletal condition preventing physical testing
* Neurological muscle weakness (e.g., stroke, spinal cord injury)
* BMI \>34.9 kg/m²
* Recent hospitalization (past 3 months)
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