Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches
Recruiting
Observational Study
Hepatocarcinoma
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
270 (estimated)
Sponsor
Niguarda Hospital · Other
Who this trial is looking for
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This is a national, observational, retrospective, cross-sectional, non-profit study focused on patients with HCC. The study aims to characterize the expression and function of novel noncoding regulatory transcripts, including those containing TEsin the microenvironment of liver tumors, with emphasis on their role in T cell dysfunction.
Trial Locations
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Status
Eligibility Criteria
1. Histological/radiological (LR-4 o 5)diagnosis of hepatocellular carcinoma (HCC).
2. Solid tumor fresh tissue availability from HCC biospy or surgical resectionas per standard clinical practice, and/orHCC FFPE archival samples availability.
3. Capability of understanding and signing an inform cons…
1. Histological/radiological (LR-4 o 5)diagnosis of hepatocellular carcinoma (HCC).
2. Solid tumor fresh tissue availability from HCC biospy or surgical resectionas per standard clinical practice, and/orHCC FFPE archival samples availability.
3. Capability of understanding and signing an inform consent form.
4. Known hepatits B and C status, including HBeAg (positive or negative), viral load (HBVDNA e HCV-RNA), HCV genotype, whether sustained virological response (SVR)was obtainedand potential antiviral treatments received (including direct antiretroviral therapy(DAA)and interferon). These parameters will be exploited to stratify patients and analyze the impact of the virological status on microenvironmental immunological features, with particular regards to immunesuppression mechanisms.
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