Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients
Recruiting
Observational Study
Sarcoma
Sarcoma, Leiomyo-, Adult
Sarcoma, Synovial, Adult
Soft Tissue Sarcoma (STS)
Soft Tissue Sarcoma Adult
Soft Tissue Sarcoma of the Trunk and Extremities
Soft Tissue Sarcoma of the Limb
Retroperitoneal Sarcoma
Liposarcoma, Dedifferentiated
Liposarcoma
Leiomyosarcoma (LMS)
Angiosarcoma
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 800 (estimated)
- Sponsor
- Royal Marsden NHS Foundation Trust · Other
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About This Trial
This is a cohort study aimed at developing a stratified medicine approach for personalised neoadjuvant chemotherapy (NCT) in high-risk soft tissue sarcoma (STS) patients with dedifferentiated liposarcoma (DDLPS), leiomyosarcoma (LMS), synovial sarcoma (SS), vascular sarcomas, malignant peripheral nerve sheath tumour (MPNST) or other subtypes. It comprises of both retrospective and prospective tiss…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Written informed consent for the prospective cohort
* Histopathological diagnosis of high-risk soft tissue sarcoma and one of the following subtypes: DDLPS, LMS, SS, vascular sarcomas or MPNST. Other subtypes may be included with PI approval.
* High-risk sarcoma definitio…
Contacts