A 12-week, randomized, placebo-controlled trial testing the efficacy of n-3 PUFA treatment (EPA, 2 g/day) in alleviating depressive symptoms in a subgroup of obese subjects with comorbid depression and low n-3 PUFA status (n-3 index \< 8%) (81), from the Taiwanese cohort. Associations with PLA2/COX2 genotypes, lifestyle, nutritional profiles and gut microbiota will also be determined.
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Eligibility Criteria
Inclusion Criteria:
* Major depressive disorder.
* Antidepressant drug-free.
Exclusion Criteria:
* Schizophrenia
* Mania
* Anxiety disorders (except for social phobia and generalized anxiety that are often comorbid with MDD)
* Obsessive-compulsive disorder
* Post-traumatic stress disorder
* Alcoh…
Inclusion Criteria:
* Major depressive disorder.
* Antidepressant drug-free.
Exclusion Criteria:
* Schizophrenia
* Mania
* Anxiety disorders (except for social phobia and generalized anxiety that are often comorbid with MDD)
* Obsessive-compulsive disorder
* Post-traumatic stress disorder
* Alcohol or drug abuse/dependence (except for nicotine)
* Active suicidal ideation
* Serious medical/neurological conditions, especially requiring corticosteroid/non-steroidal anti-inflammatory or immunosuppressive therapies or chronic thyroid hormone replacement
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