No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
200 (estimated)
Sponsor
University of Pennsylvania · Other
Who this trial is looking for
This trial is looking for adults with diabetic kidney disease who are already having a kidney procedure. Participants will provide a small blood and urine sample and allow researchers to use a slide of their kidney tissue from routine care.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 years old or older
I have been diagnosed with type 2 diabetes
I have a kidney function test showing eGFR of at least 10
I am having a kidney biopsy or surgery as part of my medical care
I can give informed consent to participate
I have kidney tissue available for research
You may not be able to join if
I cannot provide informed consent
I do not have kidney tissue available for research
Local policies prevent my tissue from being used for research
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this observational study is to learn more about kidney health in adults with diabetic kidney disease and other groups. Researchers will study kidney tissue and other samples. They want to learn how sodium-glucose cotransporter-2 (SGLT2) inhibitors, a type of diabetes medicine, may affect the kidneys. People can join only if they are already having a kidney biopsy or kidney surgery as p…
The goal of this observational study is to learn more about kidney health in adults with diabetic kidney disease and other groups. Researchers will study kidney tissue and other samples. They want to learn how sodium-glucose cotransporter-2 (SGLT2) inhibitors, a type of diabetes medicine, may affect the kidneys. People can join only if they are already having a kidney biopsy or kidney surgery as part of their regular medical care.
The main questions this study aims to answer are:
* Do people who take SGLT2 inhibitors show different biological patterns in kidney tissue than similar people who do not take them?
* Are these kidney tissue patterns linked with how kidney health changes over time?
Researchers will compare participants who take SGLT2 inhibitors with similar participants who do not take these medicines.
Participants will:
Let researchers use one stored slide of kidney tissue from their regular care (no extra research biopsy) Give a blood sample and a urine sample Let researchers review medical record information over time
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Age ≥18 years
* eGFR ≥10 ml/min/1.73 m2 based on the 2021 race-free CKD-EPI equation13
* Underwent a clinically indicated kidney biopsy, living donor biopsy, or nephrectomy (non-tumor adjacent tissue available).
* Able and willing to provide informed consent for release of one…
Inclusion Criteria:
* Age ≥18 years
* eGFR ≥10 ml/min/1.73 m2 based on the 2021 race-free CKD-EPI equation13
* Underwent a clinically indicated kidney biopsy, living donor biopsy, or nephrectomy (non-tumor adjacent tissue available).
* Able and willing to provide informed consent for release of one pathology and clinical data abstraction.
Exclusion Criteria:
* Inability to provide informed consent.
* Archived biopsy or surgical tissue unavailable for slide preparation.
* Any local institutional policy that prohibits release of H\&E slides for research.
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.