This study aims to evaluate the efficacy and safety of TIS targeting the hippocampus in ameliorating cognitive impairment associated with schizophrenia (CIAS). Participants will receive TIS twice a day for 2 weeks. Their clinical data, including the baseline clinical symptom scale score, cognitive function, and MRI data, will be collected at baseline and at the end of the 2-week intervention.
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Eligibility Criteria
Inclusion Criteria:
* Age 18-50 years old;
* meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM-5) diagnostic criteria;
* the diagnosis of schizophrenia is confirmed by the Structured Clinical Interview for DSM-5 (SCID-5);
* the disease duration does not exceed 8 yea…
Inclusion Criteria:
* Age 18-50 years old;
* meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM-5) diagnostic criteria;
* the diagnosis of schizophrenia is confirmed by the Structured Clinical Interview for DSM-5 (SCID-5);
* the disease duration does not exceed 8 years;
* 1-2 antipsychotic drugs are taken, and the treatment dose of antipsychotic drugs was stable for at least 1 week before enrollment. Mood stabilizers, antidepressants, and excessive benzodiazepines (lorazepam when 2 doses exceeded 2 mg/d) are not allowed;
* The type of antipsychotic drugs remains unchanged during treatment, and the dose is adjusted by no more than 25%;
* Impaired functioning in daily activities;
* The Global Deficit Score (GDS) for the MATRICS Consensus Cognitive Battery (MCCB) reaches 0.5 or above;
* Agree to participate in this study and provide written informed consent
Exclusion Criteria:
* Presence of other psychiatric comorbidities, intellectual disability, obvious mood symptoms, or substance use disorders (other than caffeine and/or tobacco);
* with clear drug-induced extrapyramidal reaction;
* A history of seizures, meningitis, or encephalitis;
* with contraindications to transcranial electrical stimulation;
* History of intracranial tumors or surgery;
* history of severe head trauma;
* have received other regimens of electrical or magnetic therapy in 1 month before enrollment.
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