One Gene, Two Diseases: the Pathologic Role of IGLV1-44 in AL Amyloidosis and POEMS
Recruiting
Observational Study
AL Amyloidosis
POEMS Syndrome
Multiple Myeloma
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 – 99
- Sex
- Any
- Study type
- Observational
- Participants needed
- 100 (estimated)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia · Other
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About This Trial
By detailed sequence analysis and subsequent biophysical characterization of prototypic light chains, this project aims to identify sequence fingerprints in IGLV1-44 light chains leading to AL amyloidosis and POEMS syndrome. This understanding might help improve the risk stratification and early diagnosis of patients overexpressing pathologic IGLV1-44 LCs. Moreover, the development of nanobodies e…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Biopsy-proven diagnosis of systemic AL amyloidosis, POEMS syndrome or multiple myeloma
* Planned peripheral blood sampling +/- bone marrow aspiration
* Age \> 18 years
* Willingness to allow use of clinical data and diagnostic leftovers of clinical specimens for research purpo…
Contacts