Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment
Recruiting
N/A
Interventional Study
Persistent Apical Periodontitis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 60 (estimated)
- Sponsor
- KEZBAN MELTEM ÇOLAK · Other
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About This Trial
This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well as postoperative pain.
Patients requiring non-surgical root canal retreatment will be randomly assigned to one of three irrigation concentration groups. Intracanal sampl…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients aged between 18 and 65 years.
* Systemically healthy individuals (ASA I or II)
* Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth
* Patients who provide written informed consent.
Exclusion Criteria:
* Patients with syste…
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