Autoimmune Neurological Diseases and Those Secondary to Immunotherapy: Study of Immunological Mechanisms and Research Into Targets of Immune Attack
Recruiting
N/A
Interventional Study
Neurological Diseases
Auto Immune Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 160 (estimated)
- Sponsor
- Assistance Publique - Hôpitaux de Paris · Other
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About This Trial
The pathophysiology of neurological toxicities secondary to immune checkpoint inhibitors (ICIs) is unknown. Various mechanisms have been proposed: activation of cytotoxic CD8 T cells, autoantibodies via activation of B cells and CD4 cells, non-specific inflammation through the production of pro-inflammatory cytokines, and complement activation.
The aim of this research is to characterise the path…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adult patient (aged ≥ 18 years)
* Affiliated with a social security scheme
* Express consent to participate in the study
* Indication for lumbar puncture And
* Patients with cancer, undergoing treatment with ICIs, presenting neurological symptoms after starting treatment with …
Contacts