Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1
Recruiting
Early Phase 1
Interventional Study
Healthy Adult Participants
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 60
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 32 (estimated)
- Sponsor
- Yale University · Other
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About This Trial
Evaluate \[18F\]GATT-44 (aka \[18F\]GAT44), to characterize its pharmacokinetic, metabolic, and in vivo binding profile, and assess the reproducibility of kinetic and binding parameters. Assess specific binding levels of \[18F\]GATT-44 by conducting a test-block study in humans. Estimate human dosimetry of \[18F\]GATT-44 by performing whole-body imaging studies.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Willing and able to give voluntary written informed consent;
2. Able to read and write, able to communicate effectively with the investigator, and comply with all study requirements, restrictions, and directions of the research staff;
3. Male or female, aged 18 to 60, at scre…
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