This multicenter, single-masked randomized controlled clinical trial evaluates the effectiveness of minimally-invasive non-surgical therapy (MINST) compared with standard non-surgical peri-implant therapy (NSPT) in patients diagnosed with peri-implantitis. The study investigates clinical outcomes, radiographic bone levels, patient-reported outcomes, and treatment time over 12 months.
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Eligibility Criteria
Inclusion Criteria:
* Age ≥18
* Peri-implantitis diagnosis (PPD \>6 mm, BOP+, bone loss ≥3 mm)
* Accessible implant surface without removing suprastructure
* FMPS \<30%, FMBS \<30-35%
Exclusion Criteria:
* Antibiotics in last 3 months
* Pregnancy/lactation
* Uncontrolled diabetes (HbA1c ≥7)
* Lon…
Inclusion Criteria:
* Age ≥18
* Peri-implantitis diagnosis (PPD \>6 mm, BOP+, bone loss ≥3 mm)
* Accessible implant surface without removing suprastructure
* FMPS \<30%, FMBS \<30-35%
Exclusion Criteria:
* Antibiotics in last 3 months
* Pregnancy/lactation
* Uncontrolled diabetes (HbA1c ≥7)
* Long-term SPIC (\>2 years)
* Previous implant therapy \<12 months
* Smoking/vaping in last 12 months
* Hopeless implant
* Need for adjunctive antibiotics
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