No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
50 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
90 (estimated)
Sponsor
Jérôme Bouchan · Other
Who this trial is looking for
This trial is looking for people with chronic kidney disease or rheumatoid arthritis who want to see if an exercise program can help reduce heart risks. Participants will join exercise sessions three times a week for six weeks and attend follow-up visits.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with chronic kidney disease or rheumatoid arthritis.
I have a kidney function rate between 45 and 20 ml/min or a DAS 28 score of 2.6 or higher.
I have a medical certificate saying I can safely do physical activity.
I am a beneficiary of a French social security scheme.
You may not be able to join if
I am taking more than 10 mg of prednisone per day.
I have uncontrolled high blood pressure.
I am pregnant.
I have trouble understanding or following an exercise program.
I cannot perform physical exercise for any reason.
I have legal incapacity or limited legal capacity.
I don't have health insurance.
I am currently involved in another study that could affect this one.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this clinical trial is to determine whether an aerobic exercise program can reduce cardiovascular risk in patients with systemic inflammation, such as those with rheumatoid arthritis and chronic kidney disease.
The main questions this study aims to address are:
* Does an individualized aerobic exercise program reduce cardiovascular risk, as assessed arterial stiffness and endothelial…
The goal of this clinical trial is to determine whether an aerobic exercise program can reduce cardiovascular risk in patients with systemic inflammation, such as those with rheumatoid arthritis and chronic kidney disease.
The main questions this study aims to address are:
* Does an individualized aerobic exercise program reduce cardiovascular risk, as assessed arterial stiffness and endothelial function ?
* What are the effects of this exercise program on inflammation and immunosenescence?
Researchers will compare an individualized aerobic exercise program with a therapeutic education program (consisting of educational phone calls only) and a control group with no intervention.
Participants will:
* Perform three physical activity sessions per week for six weeks (45-minute sessions at 60-80% of heart rate reserve);
* Attend clinic visits at baseline, after the 6-week intervention, and at a 6-week follow-up after the intervention;
* Undergo assessments including pulse wave velocity, hyperemic reactivity, and blood analyses.
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
* Diagnosis of Chronic Kidney Disease (CKD) or Rheumatoid Arthritis (RA), with no other risk factors related to the disease.
* Having a glomerular filtration rate between 45 and 20 ml/min/1.73 m², corresponding to stages III and IV not on dialysis for patients with CKD ; or have…
Inclusion Criteria:
* Diagnosis of Chronic Kidney Disease (CKD) or Rheumatoid Arthritis (RA), with no other risk factors related to the disease.
* Having a glomerular filtration rate between 45 and 20 ml/min/1.73 m², corresponding to stages III and IV not on dialysis for patients with CKD ; or have a DAS 28 score ≥ 2.6 points for patients with RA.
* Have a medical certificate stating that there are no adverse reactions to physical activity.
* Affiliation with a French social security scheme or beneficiary of such a scheme.
Exclusion Criteria:
* Unstabilised corticosteroid therapy and/or \>10mg prednisone/day
* Uncontrolled high blood pressure
* Pregnant women
* Impaired higher functions making it impossible to understand and adhere to an aerobic exercise program
* Inability to perform physical exercise, regardless of the cause (neurological, central or peripheral, cardiovascular or respiratory, or musculoskeletal)
* Legal incapacity or limited legal capacity
* Subject unlikely to cooperate with the study and/or low cooperation anticipated by the investigator
* Subject without health insurance
* Subject is in the exclusion period of another study involving human subjects that may interfere with the results of this study, particularly by affecting inflammatory status and the cardiovascular system.
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