Cognitive Evaluation of Patients With Eating Disorders
Recruiting
Observational Study
ARFIDAnorexia NervosaBulimia NervosaCognitive FlexibilityImplicit Association TestExecutive Functions
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
14 – 65
Sex
Any
Study type
Observational
Participants needed
84 (estimated)
Sponsor
Istituti Clinici Scientifici Maugeri SpA · Other
Who this trial is looking for
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Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this cross - sectional observational study is to improve understanding of the psychological and cognitive characteristics of Feeding and Eating Disorders (FEDs), a group of conditions that represent a growing public health concern due to their significant impact on physical health, emotional well-being, and everyday functioning. Within this broader diagnostic category, particular atten…
The goal of this cross - sectional observational study is to improve understanding of the psychological and cognitive characteristics of Feeding and Eating Disorders (FEDs), a group of conditions that represent a growing public health concern due to their significant impact on physical health, emotional well-being, and everyday functioning. Within this broader diagnostic category, particular attention is given to Avoidant/Restrictive Food Intake Disorder (ARFID), a diagnosis introduced in the DSM-5 and still relatively underexplored compared to other feeding and eating disorders.
Despite its clinical relevance, ARFID remains less well understood in terms of its underlying cognitive and psychological mechanisms. Individuals with ARFID often experience severe food avoidance or restriction that is not driven by weight or shape concerns, but rather by sensory sensitivities, fear of negative consequences of eating, or a lack of interest in food. For this reason, investigating ARFID can offer important insights into the diversity of mechanisms involved in feeding and eating disorders as a whole.
The study has two main objectives. The first objective is to examine the cognitive profile of individuals with ARFID, with a specific focus on autistic traits and cognitive flexibility, as previous research suggests potential overlaps between ARFID and neurodevelopmental conditions such as Autism Spectrum Disorders. Cognitive flexibility refers to the ability to adapt thoughts and behaviors in response to changing situations, and reduced flexibility may contribute to rigid eating patterns and food avoidance.
The second objective is to explore the role of body representation (how individuals perceive and mentally represent their own body) and inhibitory control (the ability to regulate or suppress automatic responses) in shaping the cognitive and behavioral features of ARFID and other feeding and eating disorders. These processes may help distinguish ARFID from other diagnoses and clarify shared and disorder-specific mechanisms across the FED spectrum.
The study involves adult participants of all genders, including individuals diagnosed with ARFID, anorexia nervosa, and bulimia nervosa, as well as healthy control participants without a history of feeding or eating disorders. This design allows meaningful comparisons between different diagnostic groups and with the general population.
The main questions the study aims to answer are:
Do individuals with ARFID show a distinct cognitive profile, particularly in terms of autistic traits and cognitive flexibility, compared to individuals with other feeding and eating disorders and healthy controls?
How do body representation and inhibitory control contribute to differences in eating-related behaviors across feeding and eating disorders?
Are there differences in brain activity associated with implicit, automatic attitudes toward food in individuals with feeding and eating disorders compared to healthy individuals?
Where comparison groups are included, researchers will compare participants with ARFID, anorexia nervosa, bulimia nervosa, and healthy controls to examine differences in cognitive functioning, psychological characteristics, and neural responses related to food processing.
Participants will be asked to take part in a series of non-invasive and well-established research activities, designed to be accessible and safe. These include:
Completing self-report questionnaires assessing autistic traits, body image perception, and general psychological well-being;
Performing computer-based tasks that assess cognitive flexibility and decision-making;
Completing behavioral tasks designed to measure inhibitory control and automatic associations with food-related stimuli;
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Diagnosis of a Feeding and Eating Disorder (ARFID, anorexia nervosa, or bulimia nervosa);
* Patients of both sexes;
* Age between 14 and 65 years;
* Confirmed diagnosis of a Feeding and Eating Disorder;
* Body Mass Index (BMI) \< 25;
* Signed informed consent form for particip…
Inclusion Criteria:
* Diagnosis of a Feeding and Eating Disorder (ARFID, anorexia nervosa, or bulimia nervosa);
* Patients of both sexes;
* Age between 14 and 65 years;
* Confirmed diagnosis of a Feeding and Eating Disorder;
* Body Mass Index (BMI) \< 25;
* Signed informed consent form for participation in the study.
Exclusion Criteria:
* Diagnosis of Bipolar Disorder according to DSM-5-TR criteria;
* Diagnosis of a Schizophrenia Spectrum Disorder according to DSM-5-TR criteria;
* Intellectual disability according to DSM-5-TR criteria;
* Presence of brain tumors;
* History of seizure events;
* Presence of other moderate to severe neurological disorders;
* Lack of the patient's consent to voluntary participation in the study;
* Lack of parental or legal guardian consent for participation of a minor in the study.
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