NNC0487-0111 for Obesity and Knee Osteoarthritis
A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Recruiting
Phase 3
Interventional Study
Obesity
Knee Osteoarthritis (OA)
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 400 (estimated)
- Sponsor
- Novo Nordisk A/S · Industry
Who this trial is looking for
This trial is looking for adults with knee osteoarthritis and extra body weight. Participants will receive either an injection of NNC0487-0111 or a placebo once a week to see how it helps with weight loss and pain reduction.
Are You a Good Fit for This Trial?
You may be able to join if
- I am at least 18 years old.
- I have been diagnosed with knee osteoarthritis.
- I have had pain in my target knee for more than 15 days in the past 30 days.
- I have experienced knee pain for over 90 days.
- I am willing to stop taking pain medications for 72 hours before certain visits.
You may not be able to join if
- I have a glycated hemoglobin level of 6.5% or higher.
- I have a history of type 1 or type 2 diabetes.
- I have had any joint surgery or injections in my target knee in the last 90 days.
- I have a joint prosthesis or replacement in my target knee.
- I have any other joint disease in my target knee.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
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Answer a few quick questions to see if you may meet the eligibility requirements.
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About This Trial
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment p…
Trial Locations
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Eligibility Criteria
Key inclusion Criteria:
* Male or female (sex at birth).
* Age 18 years or above at the time of signing the informed consent.
* Clinical diagnosis of knee osteoarthritis (American College of Rheumatology criteria) with radiographic changes (Kellgren Lawrence (KL) grades 2 to 3 as per central readin…
Contacts