Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features
Recruiting
Observational Study
Periodontis
Aggressive Periodontitis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 20 – 40
- Sex
- Any
- Study type
- Observational
- Participants needed
- 9 (estimated)
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine · Other
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About This Trial
The goal of this observational study is to investigate cellular heterogeneity and inflammatory microenvironment features in gingival tissues from patients with aggressive periodontitis compared to chronic periodontitis and healthy controls, using single-cell and spatial transcriptomics combined with whole-genome sequencing.
The main question(s) it aims to answer are:
What are the differences in …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
Aggressive Periodontitis Patients:
1. Aged 20-35 years
2. Radiographic evidence of at least 30% vertical bone loss at ≥2 tooth sites
3. Can be classified as Stage III/IV, Grade C periodontitis according to the 2018 new classification of periodontitis
4. With or without family h…
Contacts