Project SIRT6 Activator

Inclusion Criteria: 1. 50-80 years males; 2. Resident of Singapore (citizenship or permanent residency is not required); 3. Prefrail according to Fried frailty phenotype score; 4. English-literate who can understand, read and write in English; 5. Individuals without severe cognitive impairment, as determined by PI judgment; 6. Apparently healthy and non-smokers having not more than 2 of the following conditions. If the conditions are present they have to be stable: * Hypertension, * Hyperlipidemia, * Hyperglycemia, * Osteopenia/osteoporosis, * Osteoarthritis, * COPD, * Type 2 diabetes. Subjects who agree to shave one day before each visit if he has dense facial hairs on their cheeks that could interfere with skin microbiome sampling. Exclusion Criteria: 1. Pre-existing or history of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke, peripheral vascular disease); 2. Current cancer or non-stable chronic obstructive pulmonary disease (COPD); 3. Use of anticoagulant medication; 4. Consuming seaweed more than 3 times a week; 5. Having hairiness, moles, tattoos, scars, irritated skin, etc. on the face which could influence the investigation; 6. Having used within the 3 past weeks for more than 3 consecutive days any systemic or topical drugs related to antibiotics or having planned to use these treatments during the study; 7. Having a positive serology for HIV, HEPATITIS B, HEPATITIS C\* \*Subjects will undergo a serology test, which will be conducted at baseline and at the end of the intervention visit. Only for subjects who accepted to undergo skin microbiopsy sampling; 8. Subject with any contra-indication for skin microbiopsies: * hypersensitivity or any serious reaction to local anesthesia; (lidocaine/prilocaine), local antibiotics, and antiseptics, * with inherited or acquired hemostasis disorders, * having had any treatment which may affect the blood coagulation and hemostasis (anti-coagulant medications…), * having a history of wound healing defects (hypertrophic scars, keloids…).