Physiological Study of High PEEP in Noninvasive Ventilation
Recruiting
N/A
Interventional Study
Respiratory Failure With Hypoxia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 100
- Sex
- Any
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 50 (estimated)
- Sponsor
- Chongqing Medical University · Other
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About This Trial
To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced improvement in oxygenation.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age ≥ 18 years
2. PaCO₂ ≤ 50 mmHg
3. PaO₂/FiO₂ ≤ 300 mmHg
4. Use of a noninvasive ventilator with esophageal pressure monitoring capability (e.g., Mindray SV70) -
Exclusion Criteria:
1. Respiratory failure caused by heart failure, asthma, or acute exacerbation of chronic ob…
Contacts