Surovatamig for Chronic Lymphocytic Leukaemia

Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)

Recruiting Phase 3 Interventional Study
Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated IGHV
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Pivotal Trial This treatment is in the last trial phase before FDA approval. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 18
Sex
Any
Trial phase
Phase 3
Study type
Interventional
Purpose
Treatment
Participants needed
420 (estimated)
Sponsor
AstraZeneca · Industry
Who this trial is looking for

This trial is looking for patients with Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma who have specific genetic features. Participants will receive a treatment called Surovatamig to see if it helps improve their condition after initial therapy.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have been diagnosed with Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma.
  • I have unmutated Immunoglobulin Heavy Chain Variable (IGHV).
  • I have completed my first round of treatment.
  • I have measurable disease.
  • I have a performance status of 0 to 2.
  • I have adequate blood, liver, kidney, and heart function.
  • I am a woman not able to become pregnant or using effective birth control.
  • I am a man who will use barrier contraception if sexually active.

You may not be able to join if

  • I have had a transformation of my CLL/SLL to a more aggressive lymphoma.
  • I have evidence of my leukemia affecting my brain.
  • I have a history of progressive multifocal leukoencephalopathy.
  • I have any ongoing or past cancer.
  • I have an active infection needing treatment.
  • I have known hypersensitivity to surovatamig.
  • I have major heart issues.
  • I have had prior specific treatments for CLL/SLL.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

The purpose of this study is to evaluate the therapeutic benefit and safety of subcutaneous (SC) Surovatamig monotherapy as consolidation therapy in patients with Chronic Lymphocytic Leukaemia (CLL)/ Small Lymphocytic Lymphoma (SLL) with unmutated IGHV (uIGHV).

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Documented diagnosis of CLL/SLL with genomic features defined by unmutated IGHV. * Treatment received and response at the end of 1L (first-line) finite therapy. * Participants with SLL (except those in CR in Phase III part) must have measurable disease (nodal or extranodal) wi…
Contacts

AstraZeneca Clinical Study Information Center

1-877-240-9479

information.center@astrazeneca.com

CONTACT