NNC0487-0111 for Knee Osteoarthritis and Obesity
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Recruiting
Phase 3
Interventional Study
Obesity
Overweight
Osteoarthritis, Knee
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 400 (estimated)
- Sponsor
- Novo Nordisk A/S · Industry
Who this trial is looking for
This trial is looking for people with excess weight and knee osteoarthritis. Participants will receive an injection either of the study medicine or a placebo once a week for a set period of time.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years old or older.
- I have been diagnosed with knee osteoarthritis.
- I have pain in my target knee for more than 15 days in the last 30 days.
- I have had pain in my target knee for over 90 days.
- I am willing to stop taking pain relief medication for 72 hours before visits.
You may not be able to join if
- I have a glycated hemoglobin (HbA1c) of 6.5% or higher.
- I have a history of type 1 or type 2 diabetes.
- I have received treatment with GLP-1 receptor agonists before screening.
- I have had any joint surgery or injections in my target knee in the last 90 days.
- I have any other joint disease in my target knee.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
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About This Trial
This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment par…
Trial Locations
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Eligibility Criteria
Key Inclusion Criteria:
* Male or female (sex at birth)
* Age 18 years or above at the time of signing the informed consent
* Clinical diagnosis of knee osteoarthritis (OA) (American College of Rheumatology criteria) with radiographic changes (Kellgren Lawrence \[KL\] grades 2 to 4 as per central r…
Contacts