Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure

Inclusion criteria: Participants must meet all of the following criteria: 1. Provision of written informed consent. 2. Age ≥18 years. 3. Recent diagnosis of HFrEF, defined according to ESC criteria, established in either an inpatient or outpatient setting. 4. No prior initiation of GDMT for HF at the time of enrollment, or treatment limited to a single agent with potential disease-modifying effects prescribed for a different clinical indication. 5. Availability of adequate digital literacy, either by the patient or a caregiver, defined as the ability to use electronic devices for remote communication (phone/video calls), transmission of vital parameters (body weight, blood pressure, heart rate), and interaction with digital health tools. In cases of insufficient patient digital skills, the presence of a caregiver with adequate digital competence is acceptable. 6. Any etiology of HF is eligible, including ischemic, valvular, primary or infiltrative cardiomyopathies, iatrogenic or toxic causes, and tachycardia-induced cardiomyopathy. Exclusion Criteria: * Ongoing treatment with two or more guideline-directed heart failure medications at the time of HFrEF diagnosis * Presence of severe comorbidities or clinical instability requiring prolonged or continuous hospital management * Estimated life expectancy \<12 months * Pregnancy or breastfeeding