Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Recruiting
Phase 4
Interventional Study
Acute Heart Failure (AHF)
Cardiogenic Shock
Heart Failure
Ketones
Ketone Body Metabolism
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 12 (estimated)
- Sponsor
- Institute for Clinical and Experimental Medicine · Government
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About This Trial
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* LVEF \<35%
* Acute heart failure with low cardiac output syndrome or cardiogenic shock
Exclusion Criteria:
* Severe liver failure
* Severe acidosis
* Inability to insert nasogastric tube
* Gastric paralysis / ileus
* Repeated vomiting
* Severe hypokalemia
Contacts