Hyperthermia Combined With Hydrogen Peroxide Microneedle Patch for Viral Warts

Inclusion Criteria: 1. Age 6-65 years, male or female; 2. Clinically diagnosed with common warts, palmar/plantar/digital warts (≥1 lesion), with a Physician's Wart Assessment score ≥2 (0: no visible wart, no further treatment required; 1: visible wart, diameter \<3 mm; 2: single wart diameter ≥3 mm and \<6 mm; 3: single wart diameter ≥6 mm); 3. The subject or legal guardian is able to understand and sign the informed consent form and agrees to participate in the study. Exclusion Criteria: 1. Subjects presenting with atypical warts clinically; 2. Subjects with immune dysfunction or autoimmune diseases; 3. Pregnant or breastfeeding women; 4. Subjects who have received human papillomavirus (HPV) vaccination within the past 6 months; 5. Subjects who have undergone the following systemic treatments within the specified time frames: immunomodulators/immunosuppressants (e.g., etanercept), within 4 months; corticosteroids (inhaled and intranasal use permitted), within 1 month; 6. Subjects who have received the following treatments on or around the warts within the specified time frames: laser or other photochemical therapies (intense pulsed light, photodynamic therapy), within 3 months; immunotherapy (candida antigen), within 4 months; cryotherapy with liquid nitrogen, within 2 months; hydrogen peroxide, within 3 months; antimetabolite therapy (5-fluorouracil), within 2 months; retinoids, within 3 months; 7. Subjects with a history of the following diseases prior to enrollment: skin malignancy within the past 6 months, premalignant skin conditions (actinic keratosis) within the past 6 months, or currently in the acute progressive phase of skin or systemic diseases (e.g., psoriasis, atopic dermatitis, eczema, sun damage, etc.) or presenting with conditions (such as sunburn, open wounds) that may increase the risk of participation or interfere with evaluation; 8. Subjects with diseases affecting skin healing, such as diabetes mellitus, vitamin A deficiency, etc.; 9. Subjects with cold-sensitive conditions such as cryoglobulinemia or cold urticaria that may lead to abnormal observation results; 10. Subjects with severe dysfunction of the heart, lung, liver, kidney, hematopoietic system, or other vital organs.