The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Recruiting
Observational Study
Primary Angle-Closure Glaucoma
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
50 and older
Sex
Any
Study type
Observational
Participants needed
150 (estimated)
Sponsor
Zhongnan Hospital · Other
Who this trial is looking for
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Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
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Eligibility Criteria
Inclusion Criteria:
* Clinically diagnosed with primary angle-closure glaucoma (PACG)
* Aged ≥ 50 years, no gender restriction
* Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
* Case Group B: Undergoing glaucoma surgery with intraoperatively con…
Inclusion Criteria:
* Clinically diagnosed with primary angle-closure glaucoma (PACG)
* Aged ≥ 50 years, no gender restriction
* Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
* Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology
* Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery
Exclusion Criteria:
* Secondary glaucoma
* History of previous intraocular surgery
* Systemic diseases that can cause abnormal ocular zonules
* Other severe ocular diseases
* Long-term use of medications affecting connective tissue metabolism
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