No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
30 and older
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
930 (estimated)
Sponsor
Center for Eye Research Australia · Other
Who this trial is looking for
This trial is looking for adults over 30 with dementia or a related disease. Participants will have special eye imaging done to help researchers understand more about these conditions.
Are You a Good Fit for This Trial?
You may be able to join if
I am over 30 years old
I have been diagnosed with dementia or a neurodegenerative disease
I have had tests like genetic or blood biomarker tests to confirm my diagnosis
I can see well enough with my best correction to achieve 6/60 vision in both eyes
I am willing to participate and visit the Centre for Eye Research Australia
I will be accompanied by a friend or family member
You may not be able to join if
I cannot provide informed consent
I have eye conditions that prevent proper imaging
I have a known issue with pupil dilation
I have a health condition that could affect my safety or imaging quality
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Hyperspectral retinal imaging is a non-invasive imaging modality in which a series of images of the retina are captured using light of different wavelengths. The resulting "hypercube" of data provides a wealth of information about the retinal structure. Our group has developed evidence supporting a role for this technology in the detection of retinal amyloid beta in Alzheimer's disease. We are und…
Hyperspectral retinal imaging is a non-invasive imaging modality in which a series of images of the retina are captured using light of different wavelengths. The resulting "hypercube" of data provides a wealth of information about the retinal structure. Our group has developed evidence supporting a role for this technology in the detection of retinal amyloid beta in Alzheimer's disease. We are undertaking further studies to establish the role of this method in the assessment of people with dementia, or those at risk of Alzheimer's disease. In addition, we wish to test whether the approach may have value in other forms of dementia or neurodegenerative disease such as Parkinson's disease, Lewy-Body dementia or vascular dementia.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
1. Aged over 30 years.
2. Have dementia or a neurodegenerative disease such as Alzheimer's disease, Parkinson's disease, Lewy body dementia, Niemann-Pick type 2 or vascular dementia (age-matched and sex-matched controls will also be recruited).
3. With the exception of participa…
Inclusion Criteria:
1. Aged over 30 years.
2. Have dementia or a neurodegenerative disease such as Alzheimer's disease, Parkinson's disease, Lewy body dementia, Niemann-Pick type 2 or vascular dementia (age-matched and sex-matched controls will also be recruited).
3. With the exception of participants with Parkinson's disease and Lewy body disease, for whom clinical examination by a neurologist is sufficient to establish a clinical diagnosis of probable dementia with Lewy Body or probable Parkinson disease dementia, all participants must have previously undergone at least of one of the following tests to help to confirm a clinical diagnosis of dementia or neurodegenerative disease: genetic tests, blood biomarker tests (amyloid, tau, neurofilament light), a brain amyloid beta PET scan, or cerebrospinal fluid tests.
4. Have a minimum best corrected visual acuity level of 6/60 in both eyes and no major eye problems, such as advanced age-related macular degeneration, advanced glaucoma, or greater than moderate non-proliferative diabetic retinopathy.
5. Be willing to participate in the study and attend the Centre for Eye Research Australia.
6. Be accompanied by a friend or family member.
Exclusion Criteria:
1. Inability to provide informed consent
2. Ocular conditions preventing adequate retinal imaging (e.g., dense cataract, severe corneal opacity, vitreous haemorrhage)
3. Known contraindication to pharmacological pupil dilation
4. Any condition that, in the investigator's opinion, would compromise participant safety or image quality
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