This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis. Periodontitis is a chronic inflammatory disease that destroys tooth-supporting tissues. Smoking is a significant risk factor that worsens periodontal destruction and reduces the effectiveness of standard thera…
This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis. Periodontitis is a chronic inflammatory disease that destroys tooth-supporting tissues. Smoking is a significant risk factor that worsens periodontal destruction and reduces the effectiveness of standard therapies.
* The trial is a non-randomized comparative clinical study.
* It includes 44 adult patients diagnosed with Stage II and III periodontitis.
* The participants are divided into two equal groups: 22 current smokers and 22 non-smokers.
* Participants will undergo a baseline examination, followed by standardized non-surgical periodontal therapy consisting of scaling and root planing.
* A follow-up visit will be conducted six weeks post-therapy to repeat clinical measurements and saliva collection.
* The primary objective is to evaluate changes in salivary biomarker levels and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, Probing Pocket Depth, Clinical Attachment Level) after treatment.
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Eligibility Criteria
Inclusion Criteria:
* Systemically healthy.
* Diagnosed with Stage II and III periodontitis.
* Presence of ≥ 20 teeth (excluding third molars).
* Current smoker OR non-smoker
Exclusion Criteria:
* Presence of systemic diseases affecting the periodontium.
* Use of medications affecting inflammatio…
Inclusion Criteria:
* Systemically healthy.
* Diagnosed with Stage II and III periodontitis.
* Presence of ≥ 20 teeth (excluding third molars).
* Current smoker OR non-smoker
Exclusion Criteria:
* Presence of systemic diseases affecting the periodontium.
* Use of medications affecting inflammation.
* Received periodontal therapy in the past 6 months.
* Received antibiotic therapy in the last 3 months.
* Alcohol use.
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