Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
Recruiting
Observational Study
Intubated ICU Patients
Ventilator Associated Pneumonia ( VAP)
Immunoparalysis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 170 (estimated)
- Sponsor
- Hospital Universitari de Bellvitge · Other
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About This Trial
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients. Immunoparalysis will be assessed through monocyte HLA-DR expression and ex vivo lipopolysaccharide (LPS)-stimulated TNF-α production.
The study will include three cohorts: elderly pati…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* ≥18 years
* Mechanical ventilation expected \>48h
* Intubation between 24h pre- and 48h post- ICU admission
* Informed consent
Exclusion Criteria:
* Known severe immunosuppression, including primary immunodeficiency disorders, advanced HIV infection (AIDS), active hematologi…
Contacts
No contact information available.