Heart Stents for Heart Failure with Preserved Ejection Fraction
Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction
Recruiting
Phase 2
Interventional Study
Heart Failure With Preserved Ejection Fraction (HFPEF)
Coronary Artery Disease
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 350 (estimated)
- Sponsor
- King's College London · Other
Who this trial is looking for
This trial is looking for people with heart failure and narrowed heart arteries. Participants will receive either a heart stent or a placebo procedure that feels the same but does not include a stent.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with heart failure with preserved ejection fraction (HFpEF)
- I have symptoms of heart failure as defined by the New York Heart Association
- I have a left ventricular ejection fraction of 50% or higher
- I have an NT-pro-BNP level over 125 pg/ml in sinus rhythm
- I have at least one sign of left ventricular diastolic dysfunction
You may not be able to join if
- I am under 18 years old
- I cannot provide informed consent
- Having a stent is not possible for me
- I have a contraindication to taking clopidogrel or dual antiplatelet therapy
- I have had a heart attack or coronary surgery in the last 90 days
- I have severe chronic obstructive pulmonary disease
- My hemoglobin level is 80 g/L or lower
- I have another heart condition causing my symptoms
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
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About This Trial
HFpEF (heart failure with preserved ejection fraction) is a condition in which the heart muscle becomes stiff and can't pump blood properly. People living with HFpEF also often have coronary artery disease, where the blood vessels that supply the heart are narrowed or blocked.
It is not yet know whether opening these arteries with stents improves symptoms or quality of life with HFpEF. REPRIEVED …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1\. A diagnosis of HFpEF, defined by the European Society of Cardiology (ESC) criteria, defined as:
1. Symptoms of heart failure (New York Heart Association (NYHA) class II-IV) and
2. Left ventricular ejection fraction ≥ 50% and
3. NT-pro-BNP \> 125 pg/ml in sinus rhythm or \> …
Contacts
No contact information available.