A Phase 1b/2a Study of Budoprutug in Systemic Lupus Erythematosus (SLE)

Inclusion Criteria: 1. Aged 18 to 65 years at the time of consent. 2. Diagnosis of SLE according to the 2019 European League Against. Rheumatism and the American College of Rheumatology (ACR) classification criteria. 3. Active, seropositive disease, with SLEDAI 2K \>=6 at screening 4. Inadequate response to at least one therapeutic intervention Exclusion Criteria: 1. Active neuropsychiatric SLE. 2. Active lupus nephritis type III or IV that is expected to require induction therapy during the study or recently treated with induction therapy within 12 weeks. 3. Prior diagnosis of, or fulfills diagnostic criteria for, other autoimmune or inflammatory disease that may confound clinical assessments or increase subject risk in the study 4. Active systemic infection or history of chronic, recurrent, latent, or recent serious infections.