Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease
Recruiting
Early Phase 1
Interventional Study
Arginine Vasopressin Deficiency
Oxytocin Deficiency
Pediatric Disease
Hypopituitarism
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 7 – 21
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 20 (estimated)
- Sponsor
- Massachusetts General Hospital · Other
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About This Trial
An open-labeled, interventional pilot trial, 10 youth with AVP-D and 10 PD matched for age, sex, and BMI will be recruited from Pediatric Endocrinology and Neuroendocrinology at Massachusetts General Hospital and in the community. This study tests the hypothesis that oral estrogen/progestin will stimulate endogenous oxytocin release in control subjects. Eligible participants will receive two table…
Trial Locations
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Eligibility Criteria
Inclusion criteria (participants with AVP-D):
* AVP-D diagnosed in clinic using standard of care diagnostic tools;
* Stable pituitary hormone replacement (no change in dose of hormone replacement in six weeks prior to baseline);
* If on estrogen/progestin, female participants agree to stop for at l…
Contacts