Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis
Recruiting
Early Phase 1
Interventional Study
Cystic Fibrosis (CF)
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 26 (estimated)
- Sponsor
- University of Nottingham · Other
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Answer a few quick questions to see if you may meet the eligibility requirements.
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About This Trial
Linaclotide is a medicine used to treat constipation and irritable bowel syndrome with constipation (IBS-C). It works by acting on the surface of the gut lining, where it increases the movement of salt and water into the bowel. This softens stools, makes them easier to pass, and can also reduce gut pain
One advantage of linaclotide is that, unlike some natural substances in the gut, it is stable …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
Participant is willing and able to give informed consent for participation in the study
Not currently taking any medications (except for selective serotonin reuptake inhibitors, low dose tricyclic antidepressants, antihistamines, and oral contraceptive pill).
Aged between 18-6…
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