Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome
Recruiting
N/A
Interventional Study
Arginine Vasopressin Deficiency
Primary Polydipsia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Diagnostic
- Participants needed
- 144 (estimated)
- Sponsor
- University Hospital, Basel, Switzerland · Other
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About This Trial
The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which test patients prefer. The goal is to identify a simpler and more patient-friendly diagnostic approach.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age ≥ 18 years
2. Hypotonic polyuria/polydipsia syndrome defined as polyuria \>40ml/kg body weight/24h and polydipsia \>3l/24h; and urine osmolality \<800mOsm/L or known AVP-D based on accepted criteria
Exclusion Criteria:
1. Polyuria/polydipsia secondary to diabetes mellit…
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