Surovatamig for Antibody-mediated Kidney Disease

A Study to Assess the Effect of Surovatamig in Adult Participants With Antibody-mediated Kidney Disease

Recruiting Phase 2 Interventional Study
Primary Membranous Nephropathy
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 75
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
43 (estimated)
Sponsor
AstraZeneca · Industry
Who this trial is looking for

This trial is looking for adult participants with a specific kind of kidney disease called primary membranous nephropathy. Participants will receive a treatment called surovatamig through an injection to see how safe and effective it is.

Are You a Good Fit for This Trial?
Must be taking ACE inhibitorsAngiotensin receptor blockers
Must not be taking Corticosteroids

You may be able to join if

  • I am between 18 and 75 years old.
  • I have been diagnosed with anti-PLA2R antibody-positive primary membranous nephropathy.
  • I have been taking certain medications for my kidney condition for at least 4 weeks.
  • I have a positive test for anti-PLA2R antibodies.
  • I am up to date with required vaccinations.
  • I can give signed informed consent.

You may not be able to join if

  • I have received specific B cell therapies in the last 9 months.
  • I have had certain immunomodulatory treatments in the last 3 months.
  • I have a different cause for my kidney condition.
  • I have diabetes with a blood sugar level above 8.5%.
  • I have a history of cancer.
  • I have a history of serious immune system problems.
  • I have a significant history of chronic lung disease.
  • I have had a significant infection that my doctor thinks is important.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

The purpose of this study is to assess the safety, tolerability, pharmacokinetic, and efficacy of surovatamig administered by subcutaneous injection in adult participants with primary membranous nephropathy.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Participant must be 18 (or the legal age of consent in the jurisdiction in which the study is taking place) to 75 years of age inclusive, at the time of signing the informed consent. 2. Diagnosis of anti-PLA2R antibody-positive pMN. 3. All participants must have received SoC …
Contacts

AstraZeneca Clinical Study Information Center

1-877-240-9479

information.center@astrazeneca.com

CONTACT