The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease

Inclusion Criteria: 1. Age \>= 40 years; 2. Meet the diagnostic criteria for primary Parkinson's disease (MDS Parkinson's Disease Diagnostic Criteria (2015 Edition)); 3. No medication adjustment in the 4 weeks before and during each stimulation; 4. MDS-UPDRS III score \>= 8 points, Hoehn-Yahr score 1-4 points Exclusion Criteria: 1. Focal brain injury or severe leukoencephalopathy (Fazekas grade 3 or above) on previous head MRI/CT scans; 2. Various secondary Parkinson's syndromes (vascular Parkinson's syndrome, drug-induced Parkinson's syndrome, etc.); 3. Severe craniocerebral trauma, cranial surgery or deep brain stimulation treatment; 4. Ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc.; 5. A history of epilepsy, unexplained loss of consciousness, or taking anticonvulsant drugs for epileptic seizures; 6. Diagnosed with neuropsychiatric diseases other than Parkinson's disease; 7. A history of drug abuse or drug use; 8. Participated in any clinical trial in the past 3 months; 9. Pregnant/lactating women or subjects (including men) who plan to have children within 6 months; 10. Other situations that the researchers consider unsuitable for inclusion.