A Study to Evaluate JL18008 in Subject With HIV Immunological Non-Responders

Inclusion Criteria: 1. Age 18 to 65 years (inclusive), male or female. 2. Body mass index (BMI) 18.0 to 32.0 kg/m² (inclusive); body weight ≥50.0 kg for males and ≥45.0 kg for females. 3. Receiving combination antiretroviral therapy (cART) for at least 48 months, with a stable antiretroviral regimen for at least 3 months prior to enrollment. Maintained HIV-1 RNA below 50 copies/mL for at least 36 months (the earliest test date more than 36 months before enrollment), including transient viral blips (single HIV-1 RNA measurement between 50 and 200 copies/mL after excluding laboratory error). At least two HIV-1 RNA results \<50 copies/mL must be available (one may be from screening). 4. Immunological non-responder criteria: CD4⁺ T cell count ≤350 cells/μL within 1 year before screening. At least three CD4⁺ T cell counts ≤350 cells/μL within 4 years before enrollment, with intervals of ≥3 months between tests (the third may be from screening). 5. Willing to use effective non-pharmacological contraception with partner from screening until 3 months after study completion, and no plan for sperm/egg donation during this period. 6. Able to understand and provide written informed consent, and willing to comply with all protocol-specified visits and procedures. Exclusion Criteria: 1. Known allergy to the study drug or any of its excipients. 2. Receipt of immunosuppressants, immunomodulators, or systemic cytotoxic therapy within 3 months before screening. 3. Receipt of hormone therapy within 1 month before screening, except for daily doses ≤10 mg prednisone or equivalent. 4. History of severe autoimmune disease requiring systemic treatment or hospitalization, or any active autoimmune disease requiring treatment (including multiple sclerosis). 5. History of systemic infection (viral, bacterial, parasitic, or fungal) requiring systemic treatment and/or hospitalization, or other opportunistic infection, within 30 days before screening. 6. Active tuberculosis lesion within 30 days before screening. 7. Blood disorders associated with hypersplenism (e.g., thalassemia, hereditary spherocytosis, Gaucher's disease, autoimmune hemolytic anemia) or history of splenectomy. 8. Chronic diarrhea. 9. Severe cardiovascular disease within 6 months before screening, including myocardial infarction, unstable angina, congestive heart failure (NYHA class ≥II), or arrhythmia requiring medication. 10. Uncontrolled hypertension, defined as resting systolic blood pressure \>140 mmHg and/or diastolic blood pressure \>90 mmHg on at least two repeated measurements on different days despite antihypertensive treatment. 11. Positive hepatitis B surface antigen (HBsAg), or positive hepatitis C virus antibody (HCV-Ab) with detectable HCV-RNA, or active syphilis. 12. Any of the following laboratory abnormalities at screening: hemoglobin \<90 g/L; neutrophil count \<1.5×10⁹/L; platelet count \<100×10⁹/L; serum creatinine \>1.5× upper limit of normal (ULN); alanine aminotransferase \>2.5×ULN; aspartate aminotransferase \>2.5×ULN; alkaline phosphatase \>2.5×ULN; total bilirubin \>1.5×ULN; international normalized ratio \>1.5; activated partial thromboplastin time \>1.5×ULN. 13. Diagnosis of cancer within the screening period. 14. Severe neurological or psychiatric disease, or history of seizures. 15. History of drug abuse within 3 months before screening, or positive urine drug screen (including morphine, methamphetamine, ketamine, MDMA, THC, cocaine), or history of alcohol abuse. 16. Participation in another clinical trial with receipt of investigational drug within 3 months before screening. 17. Vaccination within 6 weeks before screening, or plan to receive any vaccination within 1 year after enrollment. 18. Pregnancy, positive pregnancy test, or breastfeeding. 19. Any other condition that, in the opinion of the investigator, makes the subject unsuitable for participation in this clinical study.