The Research of Integrated Traditional Chinese and Western Medicine on Hypothalamic Amenorrhea

Inclusion Criteria: Diagnostic criteria for functional hypothalamic amenorrhea 1. primary or secondary amenorrhea 2. Normal or low FSH levels, LH \< 5 IU/L, E2 \< 50 pg/mL 3. Exclusion of amenorrhea caused by: -Organic lesions of the hypothalamus or pituitary gland , Ovarian amenorrhea , Uterine or lower genital tract developmental abnormalities ,Drug-induced amenorrhea ,Other causes of amenorrhea Exclusion Criteria: 1. Individuals who have used relevant medications within the past 3 months 2. History of substance abuse or dependence (alcohol or drugs) within the past 3 months; heavy smokers (those consuming 20 or more cigarettes daily) 3. Individuals with severe or unstable physical illnesses, including liver, kidney, gastrointestinal, cardiovascular, cerebrovascular, respiratory, endocrine, neurological, immune, or hematological disorders; psychiatric patients 4. Lactating or pregnant women, or females within one year postpartum 5. History of allergy to the investigational drug; contraindications to Dingkundan, Bazhen Yimu Pills, or Femoston 6. Individuals with or suspected of having estrogen-sensitive tumors (e.g., endometrial cancer, breast cancer). 7. History of thromboembolic disease or thrombotic tendency. 8. Participation in another investigational drug clinical trial within 1 month prior to inclusion in this study (first interview).